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Semaglutide has consistently demonstrated better reductions in HbA1c and body weight compared to placebo and a variety of active comparators, including sitagliptin, exenatide extended release, insulin glargine, dulaglutide, canagliflozin, and liraglutide

It was first FDA-approved in 2022, also as a treatment for controlling blood sugar in people with type 2 diabetes

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Difficulty keeping medications down : If you are vomiting frequently, oral medications may not be absorbed effectively, and alternative routes of administration may be needed