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doi: 10.1038/nature14022

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Elevated levels of intracellular calcium are considered to be a key factor in the subsequent stages that may lead to growth hormone release

Scavenging free radicals, which can harm skin cells and cause inflammation, lowers oxidative stress

Additionally, a meta-analysis of multiple randomized, controlled trials confirmed that tesamorelin treatment significantly lowered visceral fat area and trunk fat, reduced hepatic fat, and was associated with a statistically significant increase in lean body mass, supporting its clinical effect on fat distribution and muscle preservation