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Knowler W, Bahnson J, Bantle J et al (2014) Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial

Further research will continue to elucidate the mechanistic pathways involved in the clinical efficacy of tirzepatide

doi: 10.1016/j.micpath.2017.07.025 22 BeissbarthJ.WilsonN.ArrowsmithB.BinksM

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It modulates inflammation by regulating the production of pro-inflammatory and anti-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-10 (IL-10) (Drge & Breitkreutz, 2000)