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KH815 has been shown to produce a more potent antitumor effect than single TOPI inhibitor-TROP2-targeting ADCs as well as the ability to overcome drug resistance in preclinical cancer models, and is currently being investigated in a phase I clinical trial in patients with advanced solid tumors (NCT06885645) 237

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doi: 10.1016/j.redox.2018.11.005 92 HempelNTrebakM

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Lipid and protein oxidative stress products were also elevated in the superior and middle temporal gyri of MCI brain [9