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Patients were assumed to continue oral semaglutide and liraglutide treatment until HbA1c exceeded 8.0% (64 mmol/mol), at which point oral semaglutide and liraglutide were discontinued and patients initiated basal insulin therapy with insulin Abasaglar (the most commonly used biosimilar insulin glargine in the UK), with a reduction in HbA1c applied based on the multivariate prediction equations for insulin-nave patients published by Willis et al

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This is where medications targeting GLP-1 and glucose-dependent insulinotropic peptide (GIP) pathways may provide additional benefit

doi: 10.1016/j.etap.2015.06.009 91 LaurettaRSansoneASansoneMRomanelliFAppetecchiaM

The hypothalamus controls all the mechanisms of hunger and satiety in mammals, irrespective of whether they are omnivores or carnivores