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No dependence on remaining beta cell function

4o, p), indicating that ITP modification can prevent rapid degradation by lysosomes after endocytosis

Protocol as for acetaminophen toxicity: 140 mg/kg IV initially: slow bolus not constant rate infusion (ammonia toxicity) then 70 mg/kg IV or PO x 3-6 (or more) treatments given at 8 to 12 hour intervals

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The SUSTAIN-6 trial demonstrated that semaglutide significantly reduced the risk of major cardiovascular events, including heart attack and stroke, in patients with type 2 diabetes and established cardiovascular disease