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N Engl J Med 292(19):9859 Ghimire P, Dhamoon AS (2023) Ketoacidosis

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Renal function : While most GLP-1 receptor agonists do not require dose adjustment for mild to moderate renal impairment, your kidney function influences medication selection and monitoring frequency

GLP-1 infusion increases natriuresis by reducing tubular sodium reabsorption and reduces hyperfiltration in obese subjects.50 Chronic treatment with arGLP-1 in patients with DM2 has shown no effect on measured GFR and effective renal plasma flow in the fasting or postprandial state, however it maintains its natriuretic effect.51 GLP-1 and its agonists induce natriuresis by inhibition of the Na+/H + exchanger type 3 in the proximal tubule, although interactions with the renin, insulin, or glucagon system cannot be excluded5254 because they reduce circulating levels of RAS components51,5355 (Fig

This helps keep us satisfied for extended periods, aiding in weight control